Journal article
Possible Reactivation of Latent Anal Human Papillomavirus Associated with Markers of Immune Dysfunction in Gay and Bisexual Men
IM Poynten, F Jin, M Molano, JM Roberts, RJ Hillman, DJ Templeton, C Law, MA Stanley, T Waterboer, A Farnsworth, CK Fairley, SM Garland, AE Grulich
Cancer Epidemiology Biomarkers and Prevention | Published : 2022
Abstract
Background: It is unknown whether reactivation of human papillomavirus (HPV) after latency occurs in the anus. We measured incidence and predictors of incident anal HPV in sexually inactive gay and bisexual men (GBM) as a surrogate of HPV reactivation. Methods: The Study of the Prevention of Anal Cancer collected data on sexual behavior, anal cytology, HPV DNA, histology and HPV serology. HPV incidence during periods when zero sexual partners were reported in the last six months at both the current and previous annual visit (“no sexual activity”) was analyzed by Cox regression using the Wei-Lin-Weissfeld method to determine uni-variable predictors. Results: Of 617 men enrolled, 525 had resul..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
We would like to acknowledge and thank the participants of the SPANC study. The SPANC study team includes Brian Acraman, Marjorie Adams, Claire Biro, Andrew Carr, Susan Carroll, Simon Comben, David Cooper, Alyssa Cornall, Leonie Crampton, Deborah Ekman, Amber Ellis, Christopher Fairley, Annabelle Farnsworth, Lance Feeney, Marko Garcia, Suzanne Garland, Andrew Grulich, Richard Hillman, Kirsten Howard, Fengyi Jin, Carmella Law, Matthew Law, Dorothy Machalek, Kirsten McCaffery, Ross McDonald, Patrick McGrath, Robert Mellor, Monica Molano, Kathy Petoumenos, Piero Pezzopane, Samuel Phillips, Mary Poynten, Garrett Prestage, Adele Richards, Jennifer Roberts, Daniel Seeds, Sepehr Tabrizi, David Templeton, Julia Thurloe, Winnie Tong, and Rick Varma. This work was supported by the National Health and Medical Research Council Program Grant (Sexually transmitted infections: causes, consequences and interventions Grant #568971; awarded to authors AE Grulich, SM Garland, and CK Fairley); and a Cancer Council New South Wales Strategic Research Partnership Program Grant (Preventing morbidity and mortality from anal cancer Grant #1311; awarded to A. E. Grulich, I.M. Poynten, F. Jin, R.J. Hillman, and J.M. Roberts). Cytological testing materials were provided by Hologic (Australia) Pty Ltd. The Kirby Institute is affiliated with the Faculty of Medicine, University of New South Wales and funded by the Australian Government of Health and Ageing.